Table 3 Hazard ratios of key variables of interest for all-cause mortality from Cox proportional hazard model after excluding subjects died in the first year.

Key variables of interest	Subjects (n = 4858)	Death (n = 431)	Person-years	Incidence density (1000 person-year)	Adjusted hazard ratio (95% confidence intervals)^a
All-cause mortality
BUN (mg/dL)
< 20	4527	342	37,704.87	9.07	1.00
≥ 20	331	89	2597.81	34.26	1.43 (1.11–1.83)**^,a
eGFR (mL/min/1.73 m²)
≥ 90	2477	59	19,721.61	2.99	1.00
< 90	2381	372	20,581.07	18.07	1.61 (1.16–2.22)**^,a
UACR (mg/g)
< 30	4240	295	35,323.96	8.35	1.00
≥ 30	618	136	4978.72	27.32	1.52 (1.22–1.90)***^,a
baPWV (cm/s)
< 1400	1758	31	14,211.92	2.18	1.00
≥ 1400	3100	400	26,090.76	15.33	1.58 (1.02–2.43)*^,a
Expanded cardiovascular disease mortality
BUN (mg/dL)
< 20	4527	98	37,704.87	2.60	1.00
≥ 20	331	39	2597.81	15.01	1.75 (1.19–2.58)**^,b
eGFR (mL/min/1.73 m²)
> 90	2477	9	19,721.61	0.46	1.00
≤ 90	2381	128	20,581.07	6.22	2.43 (1.17–5.06)*^,b
UACR (mg/g)
< 25	4134	77	34,443.99	2.24	1.00
≥ 25	724	60	5858.69	10.24	2.03 (1.43–2.88)***^,b
baPWV (cm/s)
< 1400	1758	1	14,211.92	0.07	1.00
≥ 1400	3100	136	26,090.76	5.21	14.69 (1.99–108.25)**^,b

HDL-C high density lipoprotein-cholesterol, BMI body mass index, MAP mean arterial pressure, BUN blood urea nitrogen, eGFR estimated glomerular filtration rate, UACR urine albumin-to-creatinine ratio, baPWV brachial-ankle pulse wave velocity.
*p < 0.05; **p < 0.01; ***p < 0.001.
^aAdditionally adjusted for gender, age group, type of cohort, heart disease, cerebrovascular disease, cancer, smoking habits, education level, marital status, sleep hours, low density lipoprotein-cholesterol, SBP, BMI, HDL-C, and MAP.
^bAdjusted for gender, age group, type of cohort, heart disease, cerebrovascular disease, alcohol consumption, sleep hours, and serum glutamic-pyruvic transaminase.

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