Figure 6
From: Immunomodulatory role of Parkinson’s disease 7 in inflammatory bowel disease
Effect of PARK7-binding Comp23 on the intestinal permeability of WT mice. Mucosal permeability of colon sacs derived from control and Comp23 pretreated WT mice, filled with fluorescence dextrans (4 kDa (a) and 70 kDa (b)) diluted in DMEM were investigated in the absence or presence of H2O2 (1000 μM). Permeation of dextrans were measured in every 20 min for 4 h. Results are presented as the percent of total release and illustrated as mean ± SEM. Analysis of significance was performed by two-way ANOVA test. *p < 0.05 Control vs. H2O2; **p < 0.05 H2O2 vs. Comp23 + H2O2 at given time.
