Figure 1

Periventricular leukomalacia (PVL) as depicted by MRI at a later stage after completed myelination in a 6-year-old male born at 32 weeks of gestation. Axial T2-weighted (T2w), FLAIR and T1-weighted (T1w) images at the level of the centrum semiovale cutting the upper part of the ventricles (top row) and at the level of the lateral ventricles (bottom row) show the characteristic gliosis as hyperintense high signal on the T2-weighted image and hypointense low signal on the T1-weighted image. The gliosis is best seen on FLAIR images, where the periventricular hyperintensities contrast with the hypointense CSF signal. The top row illustrates gliosis, and the bottom row additional tissue loss (mild ventricular dilatation with irregularly extended borders). From Ref.⁵.