Table 2 Uni- and multivariate analysis for survival outcomes of the patients.

From: A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer

Categories

Progression-free survival

Overall survival

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR (95%CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

Age

1.018 (1.013–1.024)

< 0.001

1.012 (1.006–1.018)

< 0.001

1.017 (1.010–1.023)

< 0.001

1.012 (1.005–1.019)

0.001

FIGO stage

I

Reference

 

Reference

 

Reference

 

Reference

 

II

2.135 (1.643–2.774)

< 0.001

1.566 (1.170–2.095)

0.003

2.773 (2.039–3.771)

< 0.001

2.224 (1.573–3.146)

0.003

III

7.044 (5.896–8.415)

< 0.001

3.814 (2.976–4.889)

< 0.001

7.883 (6.320–9.832)

< 0.001

4.596 (3.384–6.242)

< 0.001

IV

8.609 (6.785–10.925)

< 0.001

4.055 (2.995–5.489)

< 0.001

10.460 (7.914–13.826)

< 0.001

5.318 (3.772–7.599)

< 0.001

Histology

Serous

Reference

 

Reference

 

Reference

 

Reference

 

Clear-cell

0.381 (0.322–0.450)

< 0.001

1.274 (1.044–1.555)

0.017

0.431 (0.356–0.522)

< 0.001

1.508 (1.200–1.895)

< 0.001

Mucinous

0.388 (0.309–0.486)

< 0.001

1.354 (1.036–1.769)

0.027

0.566 (0.446–0.717)

< 0.001

1.996 (1.500–2.657)

< 0.001

Endometrioid

0.307 (0.248–0.379)

< 0.001

0.835 (0.662–1.053)

0.127

0.317 (0.246–0.409)

< 0.001

0.868 (0.659–1.141)

0.310

Others

0.514 (0.346–0.763)

0.001

0.870 (0.570–1.328)

0.519

0.720 (0.476–1.089)

0.120

1.386 (0.894–2.149)

0.145

CA-125*

1.321 (1.277–1.367)

< 0.001

1.056 (1.006–1.107)

 

1.283 (1.234–1.334)

< 0.001

0.992 (0.938–1.049)

0.771

Complete-staging surgery

Not performed

Reference

 

Reference

 

Reference

 

Reference

 

Performed

0.435 (0.372–0.508)

0.435

0.765 (0.638–0.917)

0.004

0.408 (0.340–0.489)

< 0.001

0.819 (0.662–1.014)

0.067

Residual tumor

None

Reference

 

Reference

 

Reference

 

Reference

 

Remained

5.068 (4.421–5.810)

< 0.001

1.587 (1.306–1.930)

< 0.001

5.437 (4.648–6.359)

< 0.001

1.901 (1.517–2.381)

< 0.001

Ascites volume

< 500 mL

Reference

 

Reference

 

Reference

 

Reference

 

500 mL ≤ 

2.450 (2.127–2.823)

< 0.001

1.098 (0.936–1.287)

0.252

2.920 (2.494–3.419)

< 0.001

1.379 (1.153–1.648)

< 0.001

Ascites cytology

Negative

Reference

 

Reference

 

Reference

 

Reference

 

Positive

3.581 (3.105–4.130)

< 0.001

1.541 (1.300–1.827)

< 0.001

3.924 (3.312–4.651)

< 0.001

1.666 (1.359–2.041)

< 0.001

Adjuvant chemotherapy

None

Reference

 

Reference

 

Reference

 

Reference

 

Performed

2.781 (2.060–3.755)

< 0.001

0.904(0.635–1.288)

0.576

2.556 (1.801–3.628)

< 0.001

0.791 (0.515–1.216)

0.286

  1. CA cancer antigen, HR hazard ratio, CI confidence interval.
  2. *Logarithmic transformed when analyzed.
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