Table 2 Thermodynamics of binding of PIMT to AuNSs of different sizes.

From: Effect of gold nanoparticles on the structure and neuroprotective function of protein L-isoaspartyl methyltransferase (PIMT)

Parameters

AuNS5

AuNS50

AuNS100

N (stoichiometry)

1.04 (± 0.04)

1.23 (± 0.05)

1.1 (± 0.05)

K (binding constant, M−1)

3.96 (± 1.03) × 105

7.34 (± 1.8) × 105

1.23 × 106 (± 4.7 × 105)

ΔH (binding enthalpy, kcal/mol)

2.97 (± 0.15)

6.73 (± 6.6)

2.07 (± 0.13)

ΔS (entropy change, cal/mol.K)

35.4

49.0

54.7

ΔG (free energy change, kcal/mol)

 − 7.6

 − 7.87

 − 14.23

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