Figure 13

Scatter diagrams of the mean intra-subject differences between Bazett corrected QTc intervals and corresponding QTcI intervals plotted against the intra-subject means of QTcI intervals. The diagrams are shown for data of all study time-points (top left panel), time-points with stable heart rate (top right panel), morning fasting time-points (bottom left panel), and morning fasting time-points with stable heart rate (bottom right panel). In each panel, the red circles and blue squares correspond to female and male subjects, respectively. The solid red and solid blue lines show the linear regressions between the intra-subject QTcI means and the mean intra-subject QTc – QTcI differences in females and males, respectively. The red shaded and blue shaded areas are the 95% confidence intervals of the regression lines; the violet areas are the overlaps between the confidence intervals of the sex-specific regressions. ms milliseconds.