Table 3 sCCA linear component formulas for lipidomics vs cognitive and behavioral measures.

From: Associations between lipids in selected brain regions, plasma miRNA, and behavioral and cognitive measures following 28Si ion irradiation

Outcome type

Time Point

Irradiation Group

sCCA component number (K1–3)

Correlation

Outcome linear component

Lipidomics linear component

Cognitive

TP1

SHAM

K1

0.952

− 0.878*train_isi3 + − 0.478*train_tone4 + − 0.018*train_isi4

0.245 × 451_305_A + − 0.186 × 1281_79_A + 0.235 × 1544_847_A + 0.922 × 290_087_H

Cognitive

TP1

SHAM

K2

0.898

− 0.917*train_tone2 + − 0.393*train_tone1 + 0.064*context_minute2

0.651 × 1544_847_A + 0.731 × 419_255_A + 0.206 × 886_546_A

Cognitive

TP1

SHAM

K3

0.761

0.033*bin_1_preference_obj_2 + 0.448*preference_obj_2 + 0.893*bin_3_preference_obj_2

0.828 × 493_165_A + 0.079 × 581_18_A + 0.144 × 708_574_A + − 0.537 × 1544_849_A

Cognitive

TP1

IRR

K1

0.770

− 0.959*bin_2_preference_obj_2 + − 0.243*tone + − 0.139*context_minute4 + − 0.033*context_minute5

x290_087_A

Cognitive

TP1

IRR

K2

0.810

− 0.972*train_tone1 + 0.054*train_isi3 + 0.068*train_tone5 + 0.077*train_tone4 + 0.204*train_isi4

x290_086_H

Cognitive

TP1

IRR

K3

0.703

− 0.974*bin_1_preference_obj_2 + − 0.076*train_tone2 + − 0.009*train_tone5 + 0.021*context_minute1 + 0.122*context_minute4 + 0.173*train_tone1

x265_147_A

Cognitive

TP2

SHAM

K1

0.749

0.067context_minute2 + 0.39context_minute3 + 0.919*context_total

− 0.276 × 1253_773_A + − 0.961 × 581_309_A

Cognitive

TP2

SHAM

K2

0.660

0.191*train_isi4 + 0.23*context_minute1 + 0.954*context_minute2

− 0.276 × 291_091_A + − 0.961 × 581_183_A

Cognitive

TP2

SHAM

K3

0.821

0.094*context_minute4 + 0.146*tone + 0.165*context_minute5 + 0.971*train_tone3

0.961 × 290_087_A + − 0.276 × 419_256_A

Cognitive

TP2

IRR

K1

0.946

0.164context_minute5 + 0.259context_minute3 + 0.952*context_total

− 0.385 × 291_091_A + − 0.923 × 581_184_A

Cognitive

TP2

IRR

K2

0.956

− 0.853bin_2_preference_obj_2 + − 0.522preference_obj_2

− 0.971 × 290_088_A + − 0.153 × 581_183_A + 0.184 × 886_553_A

Cognitive

TP2

IRR

K3

0.845

− 0.227bin_3_preference_obj_2 + 0.193train_tone3 + 0.955*train_isi2

− 0.385 × 1544_867_A + − 0.923 × 835_283_A

Cognitive

TP3

SHAM

K1

0.864

0.156*context_minute2 + 0.268*train_isi3 + 0.951*context_minute1

0.04 × 290_087_A + 0.999 × 581_183_A

Cognitive

TP3

SHAM

K2

0.884

− 0.853*train_isi1 + − 0.522*train_isi2

− 0.04 × 1604_89_H + − 0.999 × 1863_995_H

Cognitive

TP3

SHAM

K2

0.691

− 0.853train_tone1 + 0.522bin_2_preference_obj_2

− 0.04 × 1544_867_H + − 0.999 × 726_589_H

Cognitive

TP3

IRR

K1

0.834

− 0.896context_minute5 + − 0.442context_total + − 0.036*context_minute3

− 1 × 283_264_H

Cognitive

TP3

IRR

K2

0.725

− 0.081*train_tone3 + − 0.021*train_isi1 + 0.035*bin_1_preference_obj_2 + 0.283*bin_2_preference_obj_2 + 0.955*time_with_objects

− 1 × 581_183_A

Cognitive

TP3

IRR

K3

0.727

− 0.879context_minute1 + − 0.476context_total + − 0.019*context_minute4

1 × 888_641_H

Behavioral

TP1

SHAM

K1

0.555

1*ofd1_fecal

− 1 × 290_086_H

Behavioral

TP1

SHAM

K2

0.444

1*fc_cued_percent_time_frz_baseline

1 × 290_087_H

Behavioral

TP1

SHAM

K3

0.509

1*nod1_fecal

1 × 265_147_A

Behavioral

TP1

IRR

K1

0.848

− 1*nod2_fecal

1 × 290_087_H

Behavioral

TP1

IRR

K2

0.404

− 1*fc_cued_percent_time_frz_baseline

− 1 × 290_087_A

Behavioral

TP1

IRR

K3

0.659

− 1*nod1_fecal

1 × 290_087_H

Behavioral

TP2

SHAM

K1

0.638

1*nod1_fecal

− 0.978 × 1253_773_A + − 0.0592 × 1544_867_A + − 0.2 × 581_309_A

Behavioral

TP2

SHAM

K2

0.765

− 1*fc_cued_percent_time_frz_baseline

− 0.157 × 888_641_A + 0.0975 × 1544_867_H + 0.983 × 581_183_H

Behavioral

TP2

SHAM

K3

0.625

− 1*ofd1_fecal

0.276 × 1253_773_A + 0.961 × 581_309_A

Behavioral

TP2

IRR

K1

0.735

1*ofd1_fecal

− 0.152 × 1544_867_A + 0.971 × 1863_996_A + − 0.185 × 888_642_A

Behavioral

TP2

IRR

K2

0.528

1*ofd2_fecal

0.385 × 1544_87_A + 0.923 × 2127_061_A

Behavioral

TP2

IRR

K3

0.697

− 1*nod2_fecal

0.0159 × 581_184_A + − 0.933 × 682_283_A + − 0.358 × 710_314_A

Behavioral

TP3

SHAM

K1

0.733

− 1*nod2_fecal

− 0.04 × 1544_867_A + − 0.999 × 1835_964_A

Behavioral

TP3

SHAM

K2

0.593

1*fc_cued_percent_time_frz_baseline

0.04 × 1544_867_H + 0.999 × 726_589_H

Behavioral

TP3

SHAM

K3

0.603

1*nod1_fecal

0.999 × 1835_964_A + − 0.04 × 1863_995_H

Behavioral

TP3

IRR

K1

0.678

− 1*ofd1_fecal

1 × 888_641_H

Behavioral

TP3

IRR

K2

0.625

− 1*nod1_fecal

− 1 × 283_264_H

Behavioral

TP3

IRR

K3

0.618

1*nod2_fecal

− 1 × 581_183_H

  1. The top 3 sCCA components are shown for sCCA analyses relating behavioral or cognitive measures with lipidomics data. Lipid masses are specified with “_A” denoting amygdala tissue and “_H” denoting hippocampus tissue.