Figure 2

Genome-wide distribution of regions harbouring piRNA in the human placenta. (A) The bar graph depicts the number of piRNAs (y-axis) transcribed from 1, < 10, and > 10 genomic loci (x-axis). More than half of the piRNAs expressed in placenta (n = 151/297) are transcribed from a single locus, while 89.6% (n = 266) of the expressed sequences are transcribed from less than 10. (B) Circular representation of the human genome (circos plot) highlighting the chromosomal location of the 636 loci encoding the 297 placental-expressed piRNAs. The outer circle represents human chromosomes (1–22, X, Y and M, hg19 coordinates). The position of human piRNA clusters are shown in the concentric blue layer interior to the chromosomal positions. Each red dot in the green concentric circle represents one of the 636 piRNA loci.