Figure 2
From: Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma
Analysis of CTSA expression and prognostic value of HCC patients in the TCGA database. (A) The CTSA expression level in hepatocellular carcinoma was significantly higher than normal liver tissues in the GEPIA database (P < 0.05). (B,C) High CTSA expression level was associated with poor overall survival (OS) in patients with HCC in the GEPIA website and Kaplan–Meier plotters database. (D) The CTSA expression level in HCC was significantly higher than None-HCC tissues in the TCGA database (P < 0.0001). (E,F) The CTSA expression in HCC was incrementally upregulated with increasing tumor stages and neoplasm histology grades in the TCGA database. (G,H) Kaplan–Meier curves of overall survival (OS) and recurrence-free survival (RFS) among different CTSA expression among HCC patients in the TCGA database. High CTSA expression associated with poor OS (G, P = 0.0056) and RFS (H, P = 0.0029). (I) The receiver operating characteristic (ROC) curve showed that the CTSA expression level can be used as evidence to predict the prognosis of HCC patients (AUC = 0.864, P < 0.0001). (J,K) Representative images in the Human Protein Atlas database showed that the expression quantity of CTSA protein in HCC tissues (> 75%, K) was higher than normal liver tissues (< 25%, J).
