Table 2 Univariate and Multivariate Cox Regression analysis of overall survival and Recurrence-free survival in HCC patients (373 cases, TCGA database).
From: Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma
Variables | Overall survival | P-Value* | Recurrence-free survival | P-Value* |
|---|---|---|---|---|
HR (95%CI) | HR (95%CI) | |||
Univariate analysis | ||||
Gender | ||||
Male vs. female | 0.823 (0.530–1.168) | 0.275 | 0.961 (0.707–1.307) | 0.800 |
Age (years) | ||||
> 55 vs. < = 55 | 1.197 (0.832–1.721) | 0.333 | 0.924 (0.681–1.253) | 0.611 |
Vascular invasion | ||||
Yes vs. no | 1.531 (1.090–2.151) | 0.014 | 1.843 (1.373–2.474) | < 0.001 |
TNM staging | ||||
I/II vs. III/IV | 0.448 (0.318–0.632) | < 0.001 | 0.547 (0.374–0.688) | < 0.001 |
Serum AFP level (ng/ml) | ||||
> 400 vs < = 400 | 1.351 (0.956–1.908) | 0.088 | 1.399 (1.036–1.890) | 0.029 |
Neoplasm histology grades | ||||
G1/G2 vs. G3/G4 | 0.958 (0.673–1.363) | 0.810 | 0.914 (0.674–1.236) | 0.559 |
Famliy cancer history | ||||
Yes vs. no | 1.105 (0.768–1.590) | 0.590 | 0.846 (0.610–1.173) | 0.316 |
Adjancent hepatic inflammation | ||||
Yes vs. no | 0.981 (0.675–1.426) | 0.919 | 1.115 (0.818–1.519) | 0.491 |
Radiation | ||||
Yes vs. no | 1.007 (0.492–2.060) | 0.985 | 1.160 (0.645–2.087) | 0.620 |
Pharmaceutical | ||||
Yes vs. no | 0.895 (0.537–1.490) | 0.669 | 0.829 (0.539–1.274) | 0.391 |
BMI (kg/m2) | ||||
> = 24 vs. < 24 | 0.700 (0.485–1.008) | 0.055 | 0.807 (0.594–1.097) | 0.172 |
CTSA | ||||
High vs. low | 1.165 (1.147–2.274) | 0.006 | 1.564 (1.162–2.104) | 0.003 |
Multivariate analysis | ||||
Vascular invasion | ||||
Yes vs. no | 1.421 (0.968–2.085) | 0.073 | 1.651 (1.189–2.291) | 0.003 |
TNM staging | ||||
I/II vs. III/IV | 0.492 (0.346–0.700) | 0.001 | 0.653 (0.465–0.919) | 0.014 |
Serum AFP level (ng/ml) | ||||
> 400 vs < = 400 | 1.094 (0.742–1.613) | 0.651 | 1.224 (0.876–1.711) | 0.236 |
CTSA | ||||
High vs. low | 1.420 (1.001–2.013) | 0.049 | 1.347 (0.994–1.824) | 0.054 |
