Figure 2
Properties of initial responses of cortical neurons to sensory stimulation. (a) Max normalised post-stimulus time histograms (PSTHs) over a 50ms window following stimulus onset (averaged over all trials) for all 8 neuron groups (excitatory in red, inhibitory in blue) in different cortical layers (L) and a 1Hz stimulus. Smoothed with a Gaussian kernel (\(\sigma\) = 1.5 ms). (b) Normalised spike count histogram over all neurons, trials and stimuli (over 50 ms following cortical activity onset). Zero spike trials are not included. (c) Histogram of single neuron single stimulus condition did spike once reliabilities. Each value represents the proportion of trials of a stimulus condition that a single neuron spiked at least once. (d) The effect of adaptation over trials (by stimulus-frequency). Top: For each single neuron and stimulus condition combination, spike counts are normalised (mean subtracted followed by division by standard deviation). Means of these normalised spike counts (over single neuron and stimulus condition combinations) are then calculated for stimulation frequency groups (0–0.2, 1, ..., 10 Hz) and 10 trial bins (i.e. trials 0–9, ..., 90–99). These mean values are plotted with a 95% confidence interval (\(\pm 2\sigma\)) for stimulation frequencies 1, 3, 6, 10 Hz here and the remaining frequencies in Supplementary Fig. 1. Bottom: Same as for spike counts (top) but for normalised first spike times. Data for remaining frequencies shown in Supplementary Fig. 1.
