Figure 6 | Scientific Reports

Figure 6

From: Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer

Figure 6

Modelling structure of METTL1–WDR4. (A) Surface representation of the SAM binding pocket in METTL1 with color according to the electrostatic potential. The surface electrostatic potential diagram (± 5 kT/e) in METTL1 (PDB: 3CKK) was generated by PyMol; the blue areas represent positively charged areas, while the red areas represent negatively charged areas. (B) Superposition of the key residues of SAM binding pockets of human METTL1 (PDB: 3CKK) and Yeast Trm8 (PDB: 2VDU). (C) Graphic representation of the METTL1–WDR4 heterodimeric complex model. (D) Close-up view of the interaction between METTL1 and WDR4 with the key residues labeled.

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