Figure 2
Mutational Signatures based on COSMIC Signatures extrapolate the nature of mutational processes in AA ESCC. (a) T > C mutations at ATN trinucleotides constitute Signature 16, which is demonstrated by yellow color in the bar graphs showing the fraction of mutational signatures contributed to whole mutations in each tumor sample. Signatures 1, 5, 16 and 26 were found in similar proportions (percentage) across the samples of T1, T5, T6, T7, T8, and T14. (b) Samples T9, T15, T16, and T19 contained various mutational signatures, each tumor sample had a unique mutational signature combination. Bar graphs shows the percentage of each signature in the tumor samples. (c) Signature 26 was correlated with percent microsatellite instability (%MSI) in Signature 16-high samples. Pearson correlation coefficient r was 0.9954 and 95% confidence interval 0.9799 to 0.9989. R2 was calculated as 0.9908.
