Figure 1

MCM-2, Ki-67 and EGFR immunoreactivity in representative laryngeal samples. Immunodetection performed using nuclear staining for MCM-2 (a, b) and Ki-67 (c, d), and membranous staining for EGFR (e, f) labeling in laryngeal squamous cell carcinoma. There are strong reaction in early stage (a, c, e), while MCM-2, Ki-67 and EGFR expressions are downregulated in advanced stage (b, d, f).