Table 1 Calculated parameters from [18F]FTC-146 PET imaging including blarcamesine’s binding potential, total volume, volume of specific binding, S1R receptor occupancy (RO) and percent of injected dose per gram of tissue (%ID/g) in WT and Fmr1 KO mice.
Dose group | Binding potential (k3/k4) | Total volume | Volume of specific binding | % RO | %ID/g |
|---|---|---|---|---|---|
WT | |||||
1 mg/kg PRE-084 | 0.78 ± 0.12 | 13.82 ± 1.19 | 6.01 ± 0.14 | 17.64 ± 6.57 | 7.64 ± 0.24 |
0 mg/kg blarcamesine (vehicle) | 1.02 ± 0.17 | 15.27 ± 3.48 | 7.67 ± 1.81 | N/A | 7.75 ± 0.94 |
1 mg/kg blarcamesine | 0.81 ± 0.11 | 13.64 ± 2.15 | 6.03 ± 0.68 | 14.30 ± 7.63 | 6.15 ± 0.94 |
10 mg/kg blarcamesine | 0.34 ± 0.09 | 7.93 ± 1.82 | 2.02 ± 0.80 | 62.63 ± 10.23 | 3.39 ± 0.84 |
30 mg/kg blarcamesine | 0.32 ± 0.11 | 8.16 ± 1.80 | 2.03 ± 0.92 | 64.44 ± 11.89 | 3.48 ± 0.65 |
Fmr1 KO | |||||
0 mg/kg blarcamesine (vehicle) | 0.88 ± 0.07 | 15.75 ± 2.24 | 7.33 ± 0.80 | N/A | 7.64 ± 1.38 |
1 mg/kg blarcamesine | 0.85 ± 0.18 | 12.02 ± 0.21 | 5.23 ± 0.22 | 10.61 ± 5.25 | 5.27 ± 0.81 |
10 mg/kg blarcamesine | 0.51 ± 0.17 | 9.34 ± 0.85 | 3.12 ± 0.97 | 41.15 ± 19.93 | 3.73 ± 0.83 |
30 mg/kg blarcamesine | 0.31 ± 0.07 | 8.25 ± 0.66 | 1.93 ± 0.36 | 64.29 ± 8.56 | 3.21 ± 0.62 |
