Figure 3

Time-response relationship of different histamine concentrations on mean arterial pressure (MAP), heart rate (HR), respiratory frequency (RF) and respiratory minute volume (RMV). The time matched control responses after saline are given in the left panel of each row along with 1 mM concentration of histamine. The values are in mean ± SEM from 6 experiments for each concentration. An asterisk (*) indicates significant difference of responses as compared with control group [P < 0.05, two sided Dunnett’s test] and with the initial value [P < 0.05, Paired t-test] for all concentrations of histamine. Arrows indicate the point of injection of saline/histamine.