Table 1 Cardiorespiratory (CVR) changes before and after instillation of saline/histamine.

From: Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models

 

Saline/histamine

10 s before point of instillation

1 min after point of instillation

Alteration in CVR parameters (% of initial value)

MAP (mm Hg)

Saline

112.33 ± 6.91

97.50 ± 8.74

 − 13.20

Hist (1 mM)

110.00 ± 6.57

67.83 ± 9.22*

 − 39.09

Hist (10 mM)

99.17 ± 2.59

51.67 ± 3.19*

 − 47.90

Hist (100 mM)

93.00 ± 4.77

48.50 ± 6.69*

 − 47.85

HR (beats per min)

Saline

254.50 ± 7.66

253.83 ± 7.88

 − 0.26

Hist (1 mM)

243.67 ± 11.23

237.33 ± 10.77

 − 2.60

Hist (10 mM)

245.83 ± 15.89

226.17 ± 13.08

 − 8.00

Hist (100 mM)

246.67 ± 12.60

206.33 ± 14.01*

 − 16.52

RF (per min)

Saline

57.00 ± 6.87

63.83 ± 5.38

 + 12.00

Hist (1 mM)

61.33 ± 3.13

72.17 ± 5.44

 + 17.67

Hist (10 mM)

66.17 ± 4.78

77.17 ± 6.80*

 + 16.62

Hist (100 mM)

60.67 ± 7.08

86.83 ± 6.75*

 + 43.12

RMV (ml/min)

Saline

149.95 ± 12.70

152.82 ± 11.31

 + 1.91

Hist (1 mM)

151.28 ± 9.10

172.50 ± 15.51

 + 14.03

Hist (10 mM)

143.17 ± 9.29

215.77 ± 17.56*

 + 50.71

Hist (100 mM)

134.13 ± 15.19

257.45 ± 26.60*

 + 91.94

  1. MAP mean arterial pressure, HR heart rate, RF respiratory frequency, RMV respiratory minute volume. In the last column, +/− indicates increase/decrease respectively. An asterisk (*) indicates significant alteration in CVR parameters as compared with the saline control group [P < 0.05, two sided Dunnett’s test] and with the initial value [P < 0.05, Paired t-test].
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