Table 3 Alteration in cardiorespiratory (CVR) parameters with 10 mM histamine after ipsilateral somatic neurotomy (+NX), bilateral vagotomy (+VagX) and pre-treatment with lignocaine (+Ligno).

From: Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models

CVR parameters

Alteration in CVR parameters (% of initial value)

 +NX

 +VagX

 +Ligno

MAP

 − 2.44

 − 41.33

 − 6.78

RF

 + 2.35

0.00

 + 1.20

RMV

 + 0.67

 + 0.49

 + 1.04

  1. MAP mean arterial pressure, RF respiratory frequency, RMV Respiratory minute volume. + NX, + VagX and + Ligno attenuate MAP, RF and RMV parameters significantly [P < 0.05, two sided Dunnett’s test] as compared with the histamine (10 mM) only group [Table 1]. + / − indicates increase/decrease respectively.
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