Figure 5

PC-specific Ank-3 KO mice excrete a sodium load faster. Summary graph showing cumulative Na⁺ excretion as a function of time (measured every 3 h) in WT mice (black circles, where n = 4 independent trials) and PC-specific Ank-3 KO mice (black squares, where n = 4 independent trials) injected (i.p.) with a Na⁺ load (100 µL, 0.9% NaCl solution). Load introduced at time 0. Cumulative Na⁺ excretion was significant greater in PC-specific Ank-3 KO mice compared to littermate controls at 6 and 9 h after introducing the Na⁺ load. *P < 0.05 vs. WT mice.