Figure 3

Effects of niacinamide (NA) and undenatured type II collagen (UCII) supplementation on knee joint in monosodium iodoacetate (MIA)-induced osteoarthritis in rats (n = 7). Representative radiographic images (A) obtained at the end of the experiment are shown. Mean values of Kellgren- Lawrence scores are demonstrated (B) with ± standard deviations (Kruskal–Wallis followed by Mann–Whitney U; p > 0.05). Control as a non-supplemental group with no osteoarthritis-induced rats, MIA as a non-supplemental group with monosodium iodoacetate (MIA)-induced knee osteoarthritis, MIA + UCII as MIA group gavage-fed a supplemental UCII at 4 mg/kg, MIA + NA40 as MIA group gavage-fed supplemental niacinamide (NA) at 40 mg/kg, MIA + NA200 as MIA group gavage-fed a supplemental NA at 200 mg/kg, MIA + UCII + NA40 as MIA group gavage-fed both supplemental UCII at 4 mg/kg and NA at 40 mg/kg and MIA + UCII + NA200 as MIA group gavage-fed both supplemental UCII at 4 mg/kg and NA at 200 mg/kg. Oral gavage delivery of supplements was applied from d7 to d30.