Table 2 Cartilage evaluation according to the Mankin system25.

From: Niacinamide and undenatured type II collagen modulates the inflammatory response in rats with monoiodoacetate-induced osteoarthritis

Criteria

Score

Histological finding

Structure

0

Smooth intact surface

1

Slight surface irregularities

2

Pannus/surface fibrillation

3

Clefts into the transitional zone

4

Clefts into the radial zone

5

Clefts into the calcified zone

6

Total disorganization

Cells

0

Uniform cell distribution

1

Diffuse cell proliferation

2

Cell clustering

3

Cell loss

Tidemark integrity

0

Intact

1

Vascularity