Figure 3

Multivariate analysis from plasma metabolome profile of G3 versus G4 patients. (a) Score scatter plot based on the PLS-DA models to explain the diagnosis (orange for G3 and red for G4; (b) rank of the different metabolites (the top 15) identified by the PLS-DA according to the VIP coefficient on the x-axis. The most discriminating metabolites are shown in descending order of their coefficient scores. The color boxes indicate whether metabolite concentration is increased (red) or decreased (blue) in G3 vs G4; (c) ROC curve of the demographic/clinical data model; (d) ROC curve of the metabolite-only model; (e) ROC curve of the metabolite + demographic/clinical data model. The figures were drawn via MetaboAnalyst software v 4.0 (https://www.metaboanalyst.ca/).