Figure 4
From: Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis
Positive differentially expressed metabolites were identified, clustered and enriched in Covid-19 patients with pulmonary fibrosis. (a) Volcano plots of positive compounds. Red dots, significantly upregulated metabolites; green dots, significantly downregulated metabolites. (b) Heatmap of different positive metabolites (“pheatmap” package in R software v3.5.0, https://www.r-project.org/). Each row denotes a different metabolite, and each column denotes a sample. A, Covid-19 patients without pulmonary fibrosis (n = 6). B, Covid-19 patients with pulmonary fibrosis (n = 22). (c) Bubble plot of KEGG enrichment of positive metabolic pathways. The size of the circle dot denotes the number of different metabolites. RichFactor is defined as the number of differential metabolites annotated to the pathway divided by all identified metabolites annotated to the pathway.
