Figure 1 | Scientific Reports

Figure 1

From: VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway

Figure 1

Effects of VALD-3 on the cytotoxicity and proliferation of breast cancer cell lines. (A) The effect of anti-proliferation of VALD-3 on MCF-7 and MDA-MB-231 cells was measured by MTT assay. Cells were inoculated into 96-wellplate and treated with different concentrations of VALD-3 for 48 h. (B) VALD-3 inhibits proliferation of MCF-7 and MDA-MB-231 cells in a concentration-dependent manner and a time-dependent manner. MCF-7 and MDA-MB-231 cells were cultured in 96-well plates and treated with different concentrations of VALD-3 for 24 h, 48 h and 72 h, respectively; the cell viability was determined by the MTT assay. Each data are presented as the mean ± SD from four independent experiments *P < 0.05, **P < 0.01 versus control group. (C) Morphological assessment of control and VALD-3 treated breast cancer MCF-7 and MDA-MB-231 cells.

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