Figure 1
Brain nodes whose nodal network properties are associated with emotional dysregulation in young adult participants with ADHD. Results are shown for the latent variable in relation to local efficiency and clustering measures of the right insula. (a) The right insula showed a significant association with emotional dysregulation. Here the underlying parcel is shown. (b) Group-specific parameter estimates for the relation between the emotional latent variable and the topology measures (density-integrated) significantly differed between the participants with ADHD-I and ADHD-C/H as well as between participants with ADHD-C/H and controls. 95% confidence interval are displayed. Asterisks give significant group-specific differences (as calculated with χ2 difference tests) of the corresponding post-hoc two-group SEM (***p < 0.001, **p < 0.01, *p < 0.05, n.s. p > 0.05; ADHD-C/H: attention-deficit/hyperactivity disorder, combined or predominantly impulsive/hyperactive attention-deficit/hyperactivity disorder; ADHD-I: predominately inattentive attention-deficit/hyperactivity disorder). (c, d) Group-specific differences in the relation between the latent variable and topology measures exist across graphs with different density thresholds (below 0.25). p-values of the χ2 difference tests are shown. Asterisks signify significance after FDR-correction. The dashed red line represents p = 0.05. Figure (a) was created using FSLeyes (version 0.22.6, https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FSLeyes). Figures (b, c, and d) were created with R software (version 3.6.0, https://cran.r-project.org/).
