Table 2 Higher frequencies of peripheral polymorphonuclear myeloid-derived suppressor cells and regulatory T cells are detected in children with B-acute lymphoblastic leukemia.

From: Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia

Cells

Patients (n = 31)

Control (n = 27)

p-value

Total MDSCs (%)

4 ± 0.4

1.3 ± 0.1

 < 0.0001

PMN-MDSCs (%)

91.3 ± 1

87.5 ± 1

0.01

MO-MDSCs (%)

9.4 ± 0.8

11.2 ± 0.8

0.1

CD4+(%)

28.9 ± 1

40.6 ± 1

 < 0.0001

CD4+CD25+low (%)

17.8 ± 0.5

21.4 ± 0.5

 < 0.0001

CD4+CD25+high (%)

7.2 ± 0.5

4.9 ± 0.2

 < 0.0001

CD4+CD25+highFoxP3+ (Tregs)(%)

2.3 ± 0.1

1.9 ± 0.1

 < 0.0001

  1. n number, MDSCs myeloid-derived suppressor cells, PMN-MDSCs Polymorphonuclear myeloid-derived suppressor cells, MO-MDSCs monocytic myeloid-derived suppressor cells, Tregs regulatory T cells. Results expressed as mean ± SE. Student's t-test; Significant p-value < 0.05.
Back to article page