Table 4 Relation of myeloid-derived suppressor cells and regulatory T cells with the post-induction response in children with B-cell acute lymphoblastic leukemia.

From: Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia

Cells

Complete remission (n = 23)

No complete remission (n = 8)

p-value

Total MDSC (%)

3.8 ± 0.4

4.5 ± 1

0.6

PMN-MDSCs (%)

89.6 ± 1

96.2 ± 0.5

 < 0.0001

MO-MDSCs (%)

10.1 ± 0.9

7.2 ± 1

0.06

CD4+ (%)

29.6 ± 1

27 ± 3

0.3

CD4+CD25+low (%)

17.6 ± 0.6

18.3 ± 0.7

0.4

CD4+CD25+high (%)

7 ± 0.6

6.7 ± 1

0.3

CD4+CD25+highFoxP3+(Tregs) (%)

2.1 ± 0.1

2.8 ± 0.1

0.001

  1. n number, MDSCs myeloid-derived suppressor cells, PMN-MDSCs polymorphonuclearmyeloid-derived suppressor cells, MO-MDSCs monocytic myeloid-derived suppressor cells, Tregs regulatory T cells. Results expressed as mean ± S.E. Mann–Whitney U test; significant p-value < 0.05.
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