Figure 2 | Scientific Reports

Figure 2

From: Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis

Figure 2

Numbers of osteoclasts with TRAP+ multinuclear in the mandibular condyles subchondral bone of WT and AhR−/− mice treated with B[a]P. Representative sections of mouse mandibular condylar subchondral bone from corn oil- (control) or B[a]P-treated (oral gavage, 120 mg/kg) WT and AhR−/− mice are shown. (A) TRAP staining. Scale bars = 300 μm. (B) Quantitative in vivo analyses of TRAP+ cells/mm bone perimeter. Mean ± SD (n = 6 mice/group). (C–E) Expression of Trap (C), Cathepsin K (D), and Integrin β3 (E). **p < 0.01.

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