Figure 6
Detrusor muscle tissue from diabetic rats was significantly less stiff than tissue from control and sucrose-treated rats. (A) A representative bright-field image shows ex vivo tissue sections of detrusor muscle bundles investigated by atomic force microscopy (AFM) nanoindentation. (B) There was a significant reduction in tissue stiffness of detrusor muscle of diabetic rats compared with control and sucrose-treated rats, with a significant reduction in mean Young’s modulus (kPa; mean ± SD, analysed by one way ANOVA followed by Tukey’s post hoc test (control n = 4, diabetic n = 4; sucrose-treated n = 4; *p < 0.05) (C) Frequency distribution profile of Young’s modulus readings obtained from tissue of diabetic rats compared to the similar profiles of readings obtained from control and sucrose-treated rat bladders.
