Table 2 Transcriptional changes in the db/db mouse urinary bladder.
Probe ID | Gene symbol | Gene name | Rat (microarray data) | Mouse (qRT-PCR data) | ||
|---|---|---|---|---|---|---|
Fold change (diabetic vs control) | p value | Fold-change (db/db vs lean) | p value | |||
Upregulated | ||||||
1368677_at | Bdnf | Brain-derived neurotrophic factor | 7.4 | 3.92E−05 | 3.4 | 0.05 |
1381504_at | Aspn | Asporin | 4.8 | 1.08E−06 | 9.8 | 0.004 |
1388142_at | Vcan | Versican | 3.8 | 8.27E−05 | 5.2 | 0.005 |
1378225_at | Mmp14 | Matrix metallopeptidase 14 | 1.6 | 0.0113 | 3.1 | 0.0387 |
1368658_at | Cntf | Ciliary neurotrophic factor | 2.8 | 0.0003 | 3.7 | 0.0464 |
1387172_a_at | Tgfb2 | Transforming growth factor, beta 2 | 1.6 | 0.0004 | 2.2 | 0.0524 |
1383398_at | Itga8 | Integrin, alpha 8 | 3.4 | 2.82E−06 | 2.4 | 0.0479 |
1382192_at | Lyve1 | Lymphatic vessel endothelial hyaluronan receptor 1 | 3.0 | 3.43E−06 | 4.7 | 0.0003 |
1392648_at | Mrc1 | Mannose receptor, C type 1 | 2.2 | 0.0006 | 4.5 | 0.0324 |
1393113_at | Arhgap1 | Rho GTPase activating protein 1 | 2.5 | 0.0006 | 1.9 | 0.05 |
1370747_at | Fgf9 | Fibroblast growth factor 9 | 1.4 | 0.0055 | 1.3 | NS |
1376410_at | Mmp17 | Matrix metalloproteinase-17-like /// matrix metallopeptidase 17 | 1.9 | 0.0003 | 1.8 | NS |
1369113_at | Grem1 | Gremlin 1 | 27.9 | 1.69E−07 | − 1.3 | NS |
1374353_x_at | Acta2//Actc1 | Actin, alpha 2, smooth muscle, aorta /// actin, alpha, cardiac muscle 1 | 2.5 | 2.15E−05 | 2.2 | NS |
1367631_at | Ctgf | Connective tissue growth factor | 2.8 | 0.0003 | 2.3 | NS |
Downregulated | ||||||
1393069_at | Sfrp5 | Secreted frizzled-related protein 5 | − 2.1 | 8.04E−05 | 3.1 | 0.0002 |
1386881_at | Igfbp3 | Insulin-like growth factor binding protein 3 | − 2.7 | 1.17E−05 | 3.2 | 0.0197 |
1370269_at | Cyp1a1 | Cytochrome P450, family 1, subfamily a, polypeptide 1 | − 12.9 | 0.0001 | − 1.4 | 0.3298 |
1369572_at | Mcpt1 | Mast cell protease 1 | − 3.1 | 0.0293 | 49.8 | 0.0483 |
1367845_at | Nefm | Neurofilament, medium polypeptide | − 1.8 | 0.0016 | 2.1 | 0.0535 |
1393271_at | Ihh | Indian hedgehog | − 2.2 | 1.51E−06 | 3.6 | 0.086 |
1369968_at | Ptn | Pleiotrophin | − 1.8 | 6.94E−05 | − 1.1 | NS |
1387208_at | Ngb | Neuroglobin | − 3.1 | 7.57E−08 | − 1.5 | NS |
1368990_at | Cyp1b1 | Cytochrome P450, family 1, subfamily b, polypeptide 1 | − 3.0 | 0.0018 | 1.6 | NS |
1367571_a_at | Igf2 | Insulin-like growth factor 2 | − 1.6 | 0.0017 | − 1.3 | NS |
