Table 2 Impact of repeated sample collection on test performance.

	MT2 positive	MT2 negative	MT2 indeterminate	Total
a. Concordance between paired MT rRT-PCR samples (N = 74)
MT1 positive	72	0	0	72
MT1 negative	0	2	0	2
MT1 indeterminate	0	0	0	0
Total	72	2	0	74
b. Concordance between paired MT antigen samples (N = 147)
MT1 positive	39	2	0	41
MT1 negative	1	104	0	105
MT1 indeterminate	1	0	0	1
Total	41	106	0	147

	NP rRT-PCR positive	NP rRT-PCR negative	Total
c. Concordance between paired MT antigen samples and NP rRT-PCR (N = 143^a)
MT1 + MT2 antigen positive	37	2	39
MT1 + MT2 antigen negative	14	90	104
Total	51	92	143

a: McNemar’s test for agreement of positive/negative results: N/A No discordant pairs.
a: Kappa coefficient (exact 95% CI): 1.00 (N/A).
a: Overall agreement (exact 95% CI): 100% (N/A).
b: McNemar’s test for agreement of positive/negative results: p = 0.56.
b: Kappa coefficient (exact 95% CI): 0.95 (0.88–1.00).
b: Overall agreement (exact 95% CI): 97% (0.93–0.99).
c: Sensitivity (exact 95% CI): 0.73 (0.58–0.84); Specificity (exact 95% CI): 0.98 (0.92–1.00).
c: McNemar’s test for agreement of positive/negative results: p = 0.003.
c: Kappa coefficient (exact 95% CI): 0.74 (0.63–0.86).
c: Overall agreement (exact 95% CI): 88.8% (0.82–0.93).
^aDiscordant MT1 and MT2 antigen results excluded (n = 4).

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