Figure 1
From: Role of cholesterol in substrate recognition by \(\gamma\)-secretase
Representative structures of (a) \(\gamma\)-secretase or (b) \(\beta\)-CTF embedded in a cholesterol-rich DPPC membrane. Individual subunits of \(\gamma\)-secretase are indicated by colors: nicastrin (yellow), APH-1 (red), PEN-2 (green), presenilin NTF and CTF (purple and cyan, respectively). (c) Time evolution of the heavy-atom RMSD for \(\gamma\)-secretase (red), its transmembrane domain (blue) and presenilin (purple). (d) Populations of different types of secondary structures for \(\beta\)-CTF. Spatial variations in the average membrane thickness around (e) \(\gamma\)-secretase and (f) \(\beta\)-CTF. The colorscale depicts thinner (red) and thicker (blue) regions of the membrane than in the bulk. The helices are numbered in panel (e) according to their order in the \(\gamma\)-secretase subunits.
