Figure 2
From: Role of cholesterol in substrate recognition by \(\gamma\)-secretase
(A) Structural representation of the reaction coordinate used for our free energy simulations, i.e., center-of-mass distance projected on a membrane plane (xy-distance) between TM6 and TM9 of presenilin and TM of \(\beta\)-CTF. (B) The free energy profile for the substrate binding to the exosite of \(\gamma\)-secretase formed by presenilin TM6 and TM9.
