Table 3 Assessment of the diagnostic performance of clinical and imaging parameters for discriminating ASC from AIH using receiver operating characteristic (ROC) curve analyses.
AUC | 95% CI | Cut-off | Sensitivity | Specificity | |
|---|---|---|---|---|---|
Liver biochemistry | |||||
ALT | 0.59 | 0.4–0.78 | 47.50 | 0.73 | 0.63 |
AST | 0.61 | 0.43–0.79 | 32.50 | 0.73 | 0.55 |
GGT | 0.73 | 0.57–0.88 | 22.50 | 0.91 | 0.50 |
Total bilirubin | 0.45 | 0.27–0.63 | 1.61 | 1.00 | 0.16 |
IgG | 0.55 | 0.35–0.75 | 13.00 | 0.64 | 0.55 |
Gamma globulins | 0.61 | 0.4–0.82 | 15.25 | 0.55 | 0.74 |
mpMRI | |||||
PDFF | 0.45 | 0.22–0.67 | 1.60 | 0.55 | 0.61 |
cT1 | 0.59 | 0.4–0.79 | 801 | 0.71 | 0.46 |
Biliary tree parameters | |||||
Percentage of the ducts with median diameter ranging 1–3 mm | 0.5 | 0.30–0.70 | 92.32 | 0.73 | 0.42 |
Percentage of the ducts with median diameter ranging 3–5 mm | 0.52 | 0.32–0.72 | 16.43 | 0.82 | 0.32 |
Percentage of the ducts with median diameter ranging 5–7 mm | 0.64 | 0.5–0.77 | 0.43 | 0.27 | 1.00 |
Percentage points along the bile duct centreline with diameter < 1 mm | 0.52 | 0.35–0.69 | 0.014 | 0.64 | 0.53 |
Percentage points along the bile duct centreline with diameter ranging 1–3 mm | 0.50 | 0.29–0.71 | 78.17 | 0.36 | 0.74 |
Percentage points along the bile duct centreline with diameter ranging 3–5 mm | 0.51 | 0.3–0.72 | 11.48 | 0.45 | 0.74 |
Percentage points along the bile duct centreline with diameter ranging 7–9 mm | 0.66 | 0.49–0.83 | 0.02 | 0.45 | 0.87 |
Percentage points along the bile duct centreline with diameter < 9 mm | 0.68 | 0.53–0.83 | 0.01 | 0.36 | 1.00 |
Total number of strictures | 0.77 | 0.6–0.94 | 10.00 | 0.45 | 0.97 |
Sum of absolute severity of strictures | 0.77 | 0.59–0.95 | 5.20 | 0.73 | 0.76 |
Sum of relative severity of strictures | 0.77 | 0.6–0.94 | 439.82 | 0.45 | 0.97 |
Total number of dilatations | 0.79 | 0.63–0.95 | 8.50 | 0.73 | 0.79 |
Total length of dilatations (mm) | 0.72 | 0.52–0.92 | 45.67 | 0.73 | 0.74 |
Maximum dilatation diameter | 0.76 | 0.58–0.94 | 5.11 | 0.91 | 0.55 |
Sum of relative severity of candidate dilatations | 0.75 | 0.56–0.93 | 570.04 | 0.64 | 0.79 |
Number of ducts with strictures | 0.78 | 0.61–0.95 | 8.00 | 0.45 | 0.97 |
Number of ducts with dilatations | 0.79 | 0.64–0.94 | 10.50 | 0.55 | 0.89 |
Number of ducts with strictures/dilatations | 0.81 | 0.65–0.96 | 6.50 | 0.91 | 0.58 |
Total length of ducts with abnormalities (strictures and dilatations) (mm) | 0.76 | 0.59–0.94 | 140.54 | 0.55 | 0.87 |
