Figure 1

Representative eyes with and without choroidal microvasculature dropout (CMvD) having superior hemifield visual field (VF) loss. (A–D) A 53-year-old male with open-angle glaucoma (OAG) and CMvD in his right eye. (E–H) A 51-year-old male with OAG without CMvD in his right eye. Both eyes were similar in terms of age, gender, and VF severity. The CMvD(+) eye showed inferotemporal (IT) neural rim thinning (A) and superior paracentral VF loss with mean deviation (MD) of − 4.89 dB (B). In optical coherence tomography angiography (OCT-A) en-face image of the optic nerve head (ONH), loss of IT ONH vessel density (ONH-VD) adjacent to the CMvD location was observed with IT ONH-VD measured to be 51.9% (C). A horizontal B-scan revealed an intact microvasculature signal in the prelaminar tissue and anterior portion of lamina cribrosa (LC) where there was no ONH-VD loss (D1). In contrast, another horizontal B-scan showed loss of microvasculature signal in the prelaminar tissue and anterior portion of LC in the area between the 2 green arrows where there was ONH-VD loss (D2). Another horizontal B-scan showed that the loss of a microvasculature signal was also observed in the choroidal layer between the 2 orange arrows where there was a CMvD next to the presence of ONH-VD loss (D3). The red ellipse and sky blue lines indicate the ONH and β-zone parapapillary atrophy margin. The CMvD area is enclosed by the purple colored border. The CMvD(−) eye also showed IT neural rim thinning (E) and superior peripheral VF loss with MD of − 4.75 dB (F). In OCT-A en-face image of the ONH, an intact ONH-VD was observed in the IT ONH location with IT ONH-VD measured to be 67.7% (G) and intact microvasculature signal in the prelaminar tissue and anterior portion of the LC (H). All OCT-A images were created by Avanti system version 2018.1.0.37.