Figure 4

Pairwise genomic variation among Clone 1 M. massiliense isolates. Pairwise SNP distances were calculated for all Clone 1 isolates in the study (n = 58). (A) Isolate pairs are categorized as between-patient or within-patient. Between patient isolates in the same cluster (Cluster 1 or Cluster 2) are further categorized as belonging to known outbreaks (red) or as sporadic, unrelated isolates (blue). (B) The relationship between accessory gene content for Clone 1 isolate pairs, measured as % accessory genes for each isolate pair (# accessory genes/# of genes in pan genome) and core genome similarity (shown as pairwise SNP distance) is shown as a scatter plot.