Figure 4
From: The COL-4A1 polypeptide destroy endothelial cells through the TGF-β/PI3K/AKT pathway
qRT-PCR assay and RNA sequencing of control vs COL-4A1-treated HUVECs. (A) Relative PIGF, VEGF, sFLT-1, ICAM-1 and VCAM-1 mRNA expression levels in each group. (B) Volcano plot. (C) Heat map. (D) Results of GO analysis. (E) Results of KEGG enrichment analysis. PIGF placenta growth factor, VEGF vascular endothelial growth factor, sFLT-1 soluble fms-like tyrosine kinase-1, ICAM-1 intercellular cell adhesion molecule-1, VCAM-1 vascular cell adhesion molecule-1, GO Gene Otology, KEGG Kyoto Encyclopaedia of Genes and Genomes. (*P < 0.05, **P < 0.01, ***P < 0.001).
