Figure 4

Time course study of pharmacodynamics of T-518. The compound was orally administered to 10-week-old male C57BL/6J mice at 3 mg/kg, and effect on tubulin acetylation in hippocampus was measured at 0.25, 1, 2, 4, 8, 16, and 24 h post-treatment. Data are expressed as mean ± SEM, n = 5. Statistical analysis was not performed.