Figure 6
Rescue of impaired septohippocampal retrograde axonal transport in P301S tau Tg mice by T-518. Five-month-old WT and P301S tau Tg mice received 1 and 3 mg/kg T-518 or vehicle daily for 2 weeks, followed by injection of retrograde axonal tracer Fluoro-Gold into right hippocampus. Three days later, labeled neurons in the medial septum were counted in vehicle-treated, vehicle-treated Tg, and T-518-treated Tg (A). Representative image of the septal nucleus in each group was shown in (B). Data are expressed as mean ± SEM and as scatter plots, and analyzed statistically as follows: Student’s t test (**p < 0.01, WT vs. Tg), or two-tailed Shirley-Williams test (##p < 0.01, Veh vs. 1 and 3 mg/kg in Tg mice). n = 8–10. Bar = 500 μm.
