Figure 8 | Scientific Reports

Figure 8

From: A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer’s disease and tauopathy in mice

Figure 8

Restoration of impaired novel object recognition in P301S tau Tg mice by T-518. The novel object recognition test was conducted after 2 weeks of vehicle or T-518 administration (1 and 3 mg/kg). Novel object recognition performance is expressed as a preference ratio. Data are expressed as mean ± SEM and analyzed statistically as follows: Student’s t test (**p < 0.01, WT-Veh vs. Tg-Veh) or two-tailed Williams test (#p < 0.05 and ##p < 0.01, Veh vs. 1 and 3 mg/kg in Tg), n = 14 or 15.

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