Table 1 Pharmacokinetic (PK) parameter of T-518 in C57BL mice at 3 mg/kg, po.

From: A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer’s disease and tauopathy in mice

Matrices

PK parameters

Value

 

Plasma

Cmax

1037

[ng/mL]

Tmax

0.25

[h]

AUC0–24 h

1722.5

[ng·h/mL]

MRT

1.76

[h]

Hippocampus

Cmax

144

[ng/g]

Tmax

0.25

[h]

AUC0–24 h

202

[ng·h/g]

MRT

1.33

[h]

  1. Data are expressed as mean. n = 5.
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