Figure 2
From: Fast and accurate exhaustive higher-order epistasis search with BitEpi
Four examples illustrating the effects of SNVs A, B and C. Bar height (blue and orange together) represent the maximum association power (\(\beta\)), while orange visualizes the interactional component (\(\alpha\)) of the total association. From left to right: (B) SNV B strongly associated with the phenotype and none of the 2-SNV and 3-SNV combinations add considerably to the association power of SNV B. In this case, there is no interaction. (AC) Neither of SNVs shows strong association power but the combination of AC increases the association power of SNV A significantly. Adding B to the pair of AC has a minor effect on the association power. In this case, A and C strongly interact with each other. (ABC) Neither of SNVs shows strong association power. Also, 2-SNV combinations do not increase the association power of SNVs considerably. However, a combination of ABC leads to a significant increase in the association power. In this case, there is a strong 3-SNV interaction of ABC. (AC and ABC) Neither of SNVs shows strong association power but the combination of AC increases the association power of SNV A significantly. Adding B to the pair of AC further increases the association power of AC. In this case, there is a strong 2-SNV interaction of AC and a strong 3-SNV interaction of ABC.
