Table 1 Reactivation of nerve agent adducted acetylcholinesterase by LLNL-02 (1) and 2-PAM

From: Development of a CNS-permeable reactivator for nerve agent exposure: an iterative, multi-disciplinary approach

Agent

Reactivation rate, kr (min−1)

Dissociation constant, KD (µM)

Overall reactivation rate, kr2 (min−1 M−1)

2-PAM

LLNL-02

2-PAM

LLNL-02

2-PAM

LLNL-02

GB

0.06 ± 0.02

0.004 ± 0.0001

706 ± 135

551.4 ± 61.3

81 ± 16

6.8 ± 0.8

VX

0.06 ± 0.005

0.01 ± 0.0007

541 ± 155

656 ± 84

121 ± 29

20.4 ± 2.9

  1. Oxime concentration ranged from 18 µM to 2 mM. Reaction time was 30 min.
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