Table 2 Mean pharmacokinetic parameters of LLNL-02 (1) following a single IV administration of 14C-LLNL-02 to male guinea pigs.

From: Development of a CNS-permeable reactivator for nerve agent exposure: an iterative, multi-disciplinary approach

Dose (mg/kg)

t1/2α (h)

t½β (h)

AUC0-t (µg h/mL)

AUC0-inf (µg h/mL)

Vd (mL/kg)

CL (mL/h/kg)

1

0.39 ± 0.01

21.92 ± 3.49

3.88 ± 0.42

7.20 ± 1.14

4402.28 ± 247.12

167.77 ± 46.53

5

0.40 ± 0.02

17.13 ± 2.69

20.52 ± 1.93

31.50 ± 4.61

3747.90 ± 228.94

178.64 ± 35.69

10

0.25 ± 0.03

9.61 ± 0.88

25.87 ± 2.15

30.50 ± 3.39

5132.86 ± 374.57

335.60 ± 34.98

20

0.39 ± 0.06

18.94 ± 5.75

51.72 ± 6.28

87.88 ± 25.49

5341 ± 473.22

311.07 ± 74.71

  1. Data is expressed as the mean of six animals ± the standard error.
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