Figure 5
Torpor rescues memory deficits in APP/PS1 mice. (A) Torpor was induced in APP/PS1 mice. As controls, wildtype (Wt) and APP/PS1 mice were used that were refed to prevent torpor entry. All mice underwent fear conditioning on day 4 (d4) and context exposore on d5. On d6, they were tested in a novel context (NC). (B) Freezing levels were significantly diferent between groups (One-way ANOVA F2,34 = 4.646, p = 0.0164). Freezing levels were significantly lower in APP/PS1 control mice compared with wildtype control mice (14.3% ± 4.7% vs 30.7% ± 5.5%; post-hoc Fisher’s LSD; p = 0.030), confirming a memory impairment in APP/PS1 mice. Torpor rescued freezing in APP/PS1 mice up to wildtype levels (35.0% ± 4.7% vs 30.7% ± 5.5%; post-hoc Fisher’s LSD; p = 0.0063). Little freezing was observed in the NC (wildtype control: 21.3% ± 4.6%, APP/PS1 control 4.7% ± 2.0%, APP/PS1 torpor 8.5% ± 3.9%).
