Figure 3
From: THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior
Co-administration of Tetrahydrocannabinol (THC) and GABAA receptor antagonist pentylenetetrazol (PTZ) affects the THC-induced behavioral stereotypy in adult zebrafish. (A) At 1.5 mM PTZ with 1 μM THC the THC-induced Repetition Index (RI), calculated as a mean ± SEM, was not statistically different from the controls (EtOH) (ns p = 0.1578). (B) 1.5 mM PTZ and 1 mM PTZ with 1 μM THC caused significant increases in swimming velocity compared to controls (EtOH) (*p < 0.05). Controls EtOH (0.0015%) (n = 19), 1 μM THC (n = 23), 1.5 mM PTZ (n = 12), 0.2 mM PTZ + 1 μM THC (n = 6), 1 mM PTZ + 1 μM THC (n = 5), 1.5 mM PTZ + 1 μM THC (n = 12) and 2 mM PTZ + 1 μM THC (n = 6). Mean RI values of 0.2 mM PTZ (n = 6) and 2 mM PTZ (n = 6), were similar to 1.5 mM PTZ. Values without a letter in common are statistically different to the control condition (p < 0.05, Kruskal–Wallis and Dunn's multiple comparisons test).
