Figure 4
From: THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior
Co-administration of Tetrahydrocannabinol (THC) and the inverse CB1R agonist AM251 did not significantly reduce the THC-induced behavioral stereotypy in adult zebrafish. (A) At 1.8 μM AM251 with 1 μM THC the THC-induced Repetition Index (RI), calculated as a mean ± SEM, was statistically different from the controls (DMSO) (*p = 0.0279). (B) Nor did AM251 and THC co-administration affect the swimming velocity during exposure. Controls (1% DMSO, n = 6), 1 μM THC (n = 23), 1.8 μM AM251 (n = 6) and 1.8 μM AM251 + 1 μM THC (n = 12). Values without a letter in common are statistically different to the control condition (p < 0.05, One-way ANOVA and Dunnett's multiple comparisons tests for (A) and Kruskal–Wallis and Dunn's multiple comparisons test for (B)).
