Figure 5
From: THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior
Co-administration of Tetrahydrocannabinol (THC) and the inverse CB2R agonist AM630 significantly reduced the THC-induced behavioral stereotypy in adult zebrafish. (A) At 3.5 μM AM630 with 1 μM THC the THC-induced Repetition Index (RI), calculated as a mean ± SEM, was not statistically different from the controls (DMSO) (ns p > 0.9999). (B) AM630 and THC co-administration did not affect the swimming velocity during exposure. Controls (DMSO 1%, n = 6), 1 μM THC (n = 23), 3.5 μM AM630 (n = 5) and 3.5 μM AM630 + 1 μM THC (n = 6). Values without a letter in common are statistically different to the control condition (p < 0.05, Kruskal–Wallis and Dunn's multiple comparisons test).
