Figure 6
From: THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior
Co-administration of Tetrahydrocannabinol (THC) and the atypical antipsychotic sulpiride significantly reduced the THC-induced behavioral stereotypy in adult zebrafish. (A) At 10 μM sulpiride with 1 μM THC and 100 μM sulpiride with 1 μM THC, the THC-induced Repetition Index (RI), calculated as a mean ± SEM, was not statistically different from the controls (EtOH) (ns p > 0.05). (B) None of the co-administrations significantly altered the swimming velocity during exposure (ns p > 0.05). Controls (EtOH) (0.0015% (n = 19)), 1 μM THC (n = 23), 10 μM sulpiride (n = 6), 100 μM sulpiride (n = 8) 10 μM sulpiride + 1 μM THC (n = 8) and 100 μM sulpiride + 1 μM THC (n = 8). Values without a letter in common are statistically different to the control condition (p < 0.05, Kruskal–Wallis and Dunn's multiple comparisons test).
