Table 3 Voxelwise temporal changes in tumour total sodium concentration (TSC), mean diffusivity (MD) and fractional anisotropy (FA).

From: Detection of early changes in the post-radiosurgery vestibular schwannoma microenvironment using multinuclear MRI

Patient

Voxelwise Δ TSC (mM)

Mean difference (95% CI)

Voxelwise Δ MD (mm2 s−1 × 10–6)

Mean difference (95% CI)

Voxelwise Δ FA

Mean difference (95% CI)

Pre/2 weeks

Pre/8 weeks

Pre/6 months

Pre/2 weeks

Pre/8 weeks

Pre/6 months

Pre/2 weeks

Pre/8 weeks

Pre/6 months

1

3.62 (2.92,4.32)***

1.53 (1.13, 1.92)***

 

76.6 (53.5, 99.8)***

52.9 (22.0, 83.8)***

 

− 0.05 (− 0.06, − 0.04)***

− 0.03 (− 0.05, − 0.02)***

 

2a

 

− 0.84 (− 1.27 − 0.40)***

− 5.07 (− 5.65,,− 4.50)***

 

− 25.8 (− 50.5,− 1.01)*

118.31 (85.5, 151.1)***

 

− 0.02 (− 0.03,− 0.005)**

− 0.11 (− 0.13, − 0.10)***

3

12.3 (11.6, 12.9)***

 

16.0 (15.3, 16.6)***

− 176 (− 206,− 144)***

 

171 (137, 203)***

0.08 (0.07,0.09)***

 

− 0.03 (− 0.04, − 0.02)***

4

12.7 (12.4, 13.1)***

9.65 (9.24, 10.1)***

16.0 (15.6, 16.4)***

32.3 (17.2, 47.3)***

− 3.06 (− 14.5, 8.40)

233 (216, 251)***

− 0.001 (− 0.006, 0.005)

− 0.03 (− 0.03, 0.02)***

− 0.06 (− 0.06, − 0.05)***

5

0.94 (0.46, 1.41)***

− 9.03 (− 9.85, − 8.20)***

13.1 (12.6, 13.7)***

− 3.75 (− 19.6, 12.1)

90.8 (76.8, 105)***

401 (371, 430)***

0.002 (− 0.006, 0.01)

− 0.03 (− 0.04, − 0.02)***

− 0.09 (− 0.10, − 0.08***

All

8.30 (7.91, 8.67)***

3.03 (2.54, 3.52)***

12.6 (12.2, 13.0)***

0.16 (− 11.9, 12.3)

22.5 (10.1,34.9)***

263 (249, 276)***

0.01 (0.01, 0.02)***

− 0.01 (− 0.02, − 0.007)***

− 0.06 (− 0.07, − 0.05)***

  1. Statistically significant values (p ≤ 0.05) are shown in bold
  2. P value calculated using repeated measures ANOVA or repeated measures mixed-effects model. Post hoc analysis of pairwise comparisons between different timepoints was performed using the Bonferroni method.
  3. *** ≤ 0.001; ** ≤ 0.01; * ≤ 0.05.
  4. aDifference from 2 week post-treatment timepoint shown as no pre-treatment imaging dataset.
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